Background: As the major subfamily of receptor tyrosine, erythropoietin-producing hepatocellular (Eph) receptor\nhas been related to progression and prognosis in different types of tumors. However, the role and mechanism of\nEPHA3 in gastric cancer is still not well understood.\nMethods: Specimen were collected from 202 patients who underwent gastric resection for gastric adenocarcinoma.\nThe expression of EphA3 was studied using immunohistochemistry. We analyzed the clinicopathological factors and\nprognostic relevance of EphA3 expression in gastric cancer.\nResults: High expression of EphA3 was associated with male predominance (p = 0.031), differentiated histology\n(p < 0.001), depth of tumor (p = 0.002), lymph node metastasis (p = 0.001), distant metastasis (p = 0.021), liver\nmetastasis (p = 0.024), advanced stage (p < 0.001), and high HER2 [removed]p = 0.017). Relapse-free survival (RFS)\nwas significantly worse in patients with high expression of EphA3 than in those with low expression of EphA3\n(p = 0.014). Multivariate analysis for RFS showed that depth of tumor [hazard ratio (HR) 9.333, 95% confidence\ninterval (CI) 2.183ââ?¬â??39.911, p = 0.003] and lymph node metastasis [hazard ratio (HR) 5.734, 95% confidence interval\n(CI) 2.349ââ?¬â??13.997, p < 0.001] were independent prognostic factors.Conclusions: These findings suggest that high expression EphA3 may participate in metastasis and worse survival.
Loading....